Corynebacterium diphtheriae nerede bulunur?

What are the virulence factors of diphtheria?

Virulence Factors for Diphtheria For Corynebacterium diphtheriae to cause diphtheria, it must produce two virulence factors: diphtherial cord factor and diphtheria toxin. The cord factor allows the bacteria to grow in rope-like lateral aggregates to colonize in the upper respiratory tract.

What is the morphology of Corynebacterium diphtheriae?

C. diphtheriae is a pleomorphic, club-shaped, Gram positive bacillus that is catalase positive, non-motile, non-spore forming, and non-acid fast. On Gram stain, the organisms are typically described as having a “picket fence” or “Chinese character” morphology (image 3).

Which staining is used for identification of Corynebacterium diphtheriae?

To accurately identify C. diphtheriae, a Gram stain is performed to show Gram-positive, highly pleomorphic organisms with no particular arrangement. Special stains like Albert's stain and Ponder's stain are used to demonstrate the metachromatic granules formed in the polar regions.

Which species bacteria which is called as KLEB Loeffler bacillus?

discovery by Klebs and Löffler … diphtheria bacillus, known as the Klebs-Löffler bacillus. …the organism that causes diphtheria, Corynebacterium diphtheriae, commonly known as the Klebs-Löffler bacillus. Simultaneously with Émile Roux and Alexandre Yersin, he indicated the existence of a diphtheria toxin.

Is Corynebacterium diphtheriae motile?

Corynebacterium diphtheria is anaerobic, Gram-positive, non-motile, non-spore-forming, non-capsulated, toxin-producing, pleomorphic coccobacillus, which is usually club-shaped. Based on biochemical properties and colony morphology, it has four biotypes, namely, gravis, mitis, intermedius, and belfanti.

How does Corynebacterium diphtheriae cause diphtheriae?

Diphtheria is a contagious infection caused by a bacterium called Corynebacterium diphtheriae. The bacterium releases a toxin that causes a buildup of grey tissue in your throat, leading to problems with swallowing and breathing.

What does Corynebacterium diphtheriae look like?

Bacteriology. Corynebacterium diphtheriae is a slender Gram-positive bacillus, usually with one end being wider, thus giving the often-described club-shaped appearance. On culture, particularly under suboptimal conditions, characteristic bands or granules appear.

What is the pathogenesis of Corynebacterium diphtheriae?

The pathogenesis of diphtheria is based upon two primary determinants: (1) the ability of a given strain of C diphtheriae to colonize in the nasopharyngeal cavity and/or on the skin, and (2) its ability to produce diphtheria toxin.